Glial cells Non-neuronal central nervous system cells, including astrocytes and oligodendrocytes, that function to maintain homeostasis, support neurotransmission and neuronal health, and form myelin
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Alteration of several metabolic enzymes and pathways that affect KG abundance and KGDD activity have been reported in cancer, such as mutations of the genes encoding isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), changes in glutaminolysis that deplete KG, and alterations in fumarate hydratase and succinate dehydrogenase that inhibit KGDD activity 11
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Glutathione therapeutic applications Due to glutathione depletion in many diseases, clinical trials have explored ways to enhance its synthesis, including administering its precursors (mainly N-acetyl-cysteine but also L-glutamine) or providing glutathione intravenously